Serum and pulmonary uric acid in pulmonary arterial hypertension

Previous studies have suggested an association between uric acid (UA) and the severity of pulmonary arterial hypertension (PAH), but it is unknown whether UA contributes to disease pathogenesis. The aim this study was determine prognostic value circulating in era current management PAH investigate role vascular remodelling. Serum levels were determined idiopathic, heritable or anorexigen at baseline first re-evaluation French Pulmonary Hypertension Network. We studied protein xanthine oxidase (XO) voltage-driven urate transporter 1 (URATv1) lungs control patients monocrotaline (MCT) Sugen/hypoxia (SuHx) rats. Functional performed using human artery smooth muscle cells (PA-SMCs) two animal models (PH). High serum follow-up, not baseline, associated with a poor prognosis. Both generating enzyme XO URATv1 upregulated wall remodelled arteries idiopathic MCT SuHx concentrations promoted mild increase cell growth PA-SMCs, PA-SMCs. Consistent these observations, oxonic acid-induced hyperuricaemia did aggravate MCT-induced PH Finally, chronic treatment rats benzbromarone mildly attenuated impaired clinical haemodynamic profile might be used as non-invasive indicator prognosis during follow-up. Our findings also indicate that metabolism disturbed walls both experimental PAH.